Pseudomonas aeruginosa

Pseudomonas aeruginosa is an ubiquitous environmental species widely spread in soils and natural water, and an opportunistic human pathogen responsible for severe infections in immunocompromised patients. The bacteria infect the pulmonary tract, urinary tract, burns, wounds, and also cause blood infections. Due to its large occurrence in hospital water systems and its capacity to persist on medical devices, P. aeruginosa is a leading cause of hospital-acquired pneumonia. Multidrug resistant (MDR) P. aeruginosa infections in the hospital setting are a serious concern, particularly for immunocompromised or intensive care unit (ICU) patients.

P. aeruginosa is the major pathogen in cystic fibrosis (CF) lung pathology. The persistence of chronic P. aeruginosa lung infections in CF patients is due to the production of a polymer matrix by mucoid strains growing inside biofilms leading to increased tolerance to antibiotics and phagocytosis.